abstract：:The phenotypic expression of cells derived from human anaplastic astrocytomas, rat glioma, normal human adult and foetal brain tissue have been examined for differentiated and malignancy-associated properties. Glial fibrillary acidic protein (GFAP), high affinity glutamate and gamma-amino butyric acid (GABA) uptake an...

journal_title：British journal of cancer

authors： Frame MC,Freshney RI,Vaughan PF,Graham DI,Shaw R

更新日期：1984-03-01 00:00:00

abstract：:In haemagglutination tests we have found that the monoclonal antibody B5 discriminates between erythrocytes from patients with malignant cancer (total 386; greater than 80% B5 positive) and individuals with no known tumour (total 247; less than 20% B5 positive). The B5 antigen detected on intact erythrocytes is a tigh...

journal_title：British journal of cancer

authors： Metcalfe S,Milner J,Svvennsen RJ

更新日期：1984-03-01 00:00:00

abstract：:Monoclonal and polyclonal antibodies against placental alkaline phosphatase (PLAP) were evaluated for tumour immunolocalization of human PLAP-producing Hep 2 tumours in nude mice. The antibodies were labelled with 125I and injected i.p. in mice with developing Hep 2 tumours. The distribution of 125I-anti PLAP in vario...

journal_title：British journal of cancer

authors： Jeppsson A,Wahren B,Millán JL,Stigbrand T

更新日期：1984-02-01 00:00:00

abstract：:The reactivation of U.V.-irradiated adenovirus 2 in HeLa cells is enhanced 8-9 fold if the cells are given a brief hyperthermic shock before infection. Maximum reactivation is achieved by heating for 10 min at 45.5 degrees C and with a delay of 36 h between heating and infection. The induction process requires protein...

journal_title：British journal of cancer

authors： Piperakis SM,McLennan AG

更新日期：1984-02-01 00:00:00

abstract：:Comparison of 9 and 35 GHz spectra, obtained from frozen and lyophilized tissues, with those from model systems containing ascorbic acid, confirm that the major component of the "lyophilization signal" of tissue is the ascorbyl radical, stabilized by adsorption on an inert matrix. The magnitude of the signal under ano...

journal_title：British journal of cancer

authors： Dodd NJ,Swartz HM

更新日期：1984-01-01 00:00:00

abstract：:Between 1946 and 1976 over 9,000 women with breast cancer were seen within one year of diagnosis at the A. Maxwell Evans Clinic (AMEC) in Vancouver, British Columbia. By 1978, 275 had a subsequent diagnosis of a second primary in the contralateral breast: 100 were diagnosed within 1 year, and 175 after 1 year of the f...

journal_title：British journal of cancer

authors： Hislop TG,Elwood JM,Coldman AJ,Spinelli JJ,Worth AJ,Ellison LG

更新日期：1984-01-01 00:00:00

abstract：:The effect on cell-cycle progression in various phases of the cell cycle caused by an acute exposure to hypoxia in absence and presence of misonidazole (MISO) was investigated. Exponentially growing and synchronized cells of the human line NHIK 3025 were exposed to different degrees of hypoxia for a short period (1.5 ...

journal_title：British journal of cancer

authors： Pettersen EO,Lindmo T

更新日期：1983-12-01 00:00:00

abstract：:The ability of human tumour cells to form colonies in soft agar is enhanced by the presence of autologous phagocytic/adherent cells. We investigated the effect of irradiation on the ability of the adherent cells to support human tumour colony formation. Relatively low doses of irradiation significantly increased the g...

journal_title：British journal of cancer

authors： Hamburger AW,White CP,Dunn FE

更新日期：1983-11-01 00:00:00

abstract：:Nabilone, a synthetic cannabinoid, and Prochlorperazine were compared in a double-blind crossover study of 34 patients with lung cancer undergoing a 3-day schedule of chemotherapy with Cyclophosphamide, Adriamycin and Etoposide. Symptom scores were significantly better for patients on nabilone for nausea, retching and...

journal_title：British journal of cancer

authors： Ahmedzai S,Carlyle DL,Calder IT,Moran F

更新日期：1983-11-01 00:00:00

abstract：:The work presented here has concerned the study of early, as well as late, enzymic changes occurring during diethylnitrosamine-induced hepatocarcinogenesis and liver regeneration after partial hepatectomy in comparison with normal liver differentiation. Rank correlation analysis of the enzyme data suggested a step-wis...

journal_title：British journal of cancer

authors： Curtin NJ,Snell K

更新日期：1983-10-01 00:00:00

abstract：:Human monocytes can be induced to synthesize a cytotoxin which affects certain tumour cell lines. The interaction of monocyte cytotoxin with a susceptible cell line (L929) has been studied to obtain clues to the mode of action of the cytotoxin. The cytotoxin acts directly on the cells rather than on the culture medium...

journal_title：British journal of cancer

authors： Matthews N

更新日期：1983-09-01 00:00:00

abstract：:Seventy three children with rhabdomyosarcoma were treated by members of the Children's Solid Tumour Group during the period, 1974-1981. The extent of disease at diagnosis was found to be the major influence affecting outcome. Children with tumours confined to the tissue of origin with no evidence of nodal or metastati...

journal_title：British journal of cancer

authors： Kingston JE,McElwain TJ,Malpas JS

更新日期：1983-08-01 00:00:00

abstract：:The incidence of B cell leukaemia in 186 consecutive untreated patients with histologically defined B cell neoplasms is described. The lymphomas were classified by the Kiel convention. B cell leukaemia in the context of this paper refers to the situation where a neoplastic clone of B cells in the blood greatly outnumb...

journal_title：British journal of cancer

authors： Cader A,Richardson P,Walsh L,Ling NR,MacLennan IC,Jones EL,Leyland M

更新日期：1983-08-01 00:00:00

abstract：:Photoradiation therapy of cancer in the presence of haematoporphyrin derivative is based on a retention of porphyrin in malignant tissue. After long term incubation of NHIK 3025 cells in the presence of 25 microgram ml-1 haematoporphyrin derivative, one fraction is easily removed from the cells by washing with a serum...

journal_title：British journal of cancer

authors： Christensen T,Sandquist T,Feren K,Waksvik H,Moan J

更新日期：1983-07-01 00:00:00

abstract：:In vitro cloned lines derived from a primary nickel-induced rat rhabdomyosarcoma exhibited diverse levels of susceptibility to spontaneous NK activity. The presence of NK target structures was revealed by competition assays on all cloned cell lines, and the NK susceptibility of the tumour lines varied according to the...

journal_title：British journal of cancer

authors： Poupon MF,Judde JG,Pot-Deprun J,Sweeney F,Lespinats G

更新日期：1983-07-01 00:00:00

abstract：:Clonal subpopulations of different ploidy values and metastatic capacities, isolated from the RIF-1 mouse sarcoma, have been tested for in vitro X-radiation sensitivity, for in vitro sensitivity to adriamycin and for in vitro and in vivo sensitivity to melphalan and CCNU. Following X-radiation, no consistent differenc...

journal_title：British journal of cancer

authors： Reeve JG,Wright KA,Twentyman PR

更新日期：1983-06-01 00:00:00

abstract：:Cell fusion has been used to analyse the genetic determinants of metastasis at the cellular level. Highly metastatic mouse melanoma cells were fused with diploid mouse lymphocytes and a range of hybrid clones isolated and tested for tumorigenicity and metastatic potential by s.c. injection into newborn, histocompatibl...

journal_title：British journal of cancer

authors： Sidebottom E,Clark SR

更新日期：1983-03-01 00:00:00

abstract：:Soluble and nuclear oestrogen receptor status was determined in both the central and peripheral portions of tumour for 37 cases of adenocarcinoma of the endometrium. Of these, 29 had functional receptor in the peripheral biopsy, but only 19 retained functional receptor in the centre. Six of the 10 patients whose tumou...

journal_title：British journal of cancer

authors： Castagnetta L,Lo Casto M,Mercadante T,Polito L,Cowan S,Leake RE

更新日期：1983-02-01 00:00:00

abstract：:The presence of succinyl-coenzyme A: acetoacetate CoA--transferase (3-oxo acid-CoA transferase), an initiator of ketone body utilization in non-hepatic tissue was examined in a number of animal and human tumours of peripheral tissues. While enzyme levels in heart, kidney, lymphocytes and bladder were high, the tumours...

journal_title：British journal of cancer

authors： Tisdale MJ,Brennan RA

更新日期：1983-02-01 00:00:00

abstract：:Previous studies have characterized the enzymatic properties and inhibition of a trypsin-like neutral protease on the surface of Ehrlich ascites cells by means of kinetic analysis. The present study links these kinetic studies with the recently reported role of a tumour-cell membrane-bound serine protease in tumour-in...

journal_title：British journal of cancer

authors： Steven FS,Hulley TP,Griffin MM,Itzhaki S

更新日期：1982-12-01 00:00:00

abstract：:Tumour cells from 7 patients with ovarian carcinoma and from 22 different human tumour xenografts representing a wide range of histological sub-types have been examined for multicellular spheroid forming ability. Spheroid formation was limited to cells derived from xenografts. Of the 22 lines tested, 5 formed spheroid...

journal_title：British journal of cancer

authors： Jones AC,Stratford IJ,Wilson PA,Peckham MJ

更新日期：1982-12-01 00:00:00

abstract：:The NCA (nonspecific cross-reacting antigen) was assayed in sera of patients with chronic myeloid leukaemia (CML). It was elevated to a mean value of 145·6 ng/ml (± 104·4 ng/ml) compared to 37·8 ng/ml (± 14·6 ng/ml) the sera of normal subjects. Patients with active disease generally had higher serum NCA levels than th...

journal_title：British journal of cancer

authors： Frénoy N,Ben-Bunant M,Berruel C,Child JA,Gendron MC,Missett JL,Razafimahaleo E,Burtin P

更新日期：1982-11-01 00:00:00

abstract：:The widely held belief that 2-naphthylamine is not carcinogenic for the rat has been re-examined. Twenty female Wistar rats were dosed by gastric intubation weekly for 57 weeks with 2-naphthylamine, 300 mg/kg body wt, in arachis oil and 20 controls were given arachis oil alone. Animals which became moribund were kille...

journal_title：British journal of cancer

authors： Hicks RM,Wright R,Wakefield JS

更新日期：1982-10-01 00:00:00

abstract：:The natural history of 45 cases of smouldering leukaemia has been studied. Males and females were equally represented, with a median age of 60.5. The median survival of the whole group was only 20 months, but rare cases lived 10 years or longer. 38% developed acute leukaemia; the remainder usually died of the results ...

journal_title：British journal of cancer

authors： Joseph AS,Cinkotai KI,Hunt L,Geary CG

更新日期：1982-08-01 00:00:00

abstract：:Monoclonal antibodies to epithelial-cell antigenic determinants, labelled with 123I and 125I, were administered parenterally to immunodeficient mice bearing human tumours derived from a human cancer cell line. Anterior, posterior and lateral radioscans of the body were taken with a gamma scintillation camera at variou...

journal_title：British journal of cancer

authors： Epenetos AA,Nimmon CC,Arklie J,Elliott AT,Hawkins LA,Knowles RW,Britton KE,Bodmer WF

更新日期：1982-07-01 00:00:00

abstract：:The geographical distribution of mortality from mesothelioma of the pleura during the years 1968-78 in England and Wales has been studied using extracts from the death records held by the Office of Population Censuses and Surveys. Using the national death rate as standard, Local Authority areas with raised mortality a...

journal_title：British journal of cancer

authors： Gardner MJ,Acheson ED,Winter PD

更新日期：1982-07-01 00:00:00

abstract：:A Phase I study of oral daily misonidazole (MISO) with conventional pelvic irradiation, has been conducted in patients with carcinoma of the cervix Stages IB, IIB, IIIB and IVA. MISO was administered in daily dosages to sequential groups of patients at doses of 0.15 g/m2, 0.30 g/m2 or 0.45 g/m2 for 22 days over 5 week...

journal_title：British journal of cancer

authors： Thomas GM,Rauth AM,Black BE,Cummings BJ,Sorenti VL,Bush RS

更新日期：1982-06-01 00:00:00

abstract：:The antitumour activities of N-methylformamide, N-ethylformamide and formamide against a number of murine tumours in vivo (Sarcoma 180, M5076 ovarian sarcoma and TLX5 lymphoma) have been estimated. In all cases N-methyl-formamide had significant activity, formamide had marginal or no activity and N-ethylformamide had ...

journal_title：British journal of cancer

authors： Gescher A,Gibson NW,Hickman JA,Langdon SP,Ross D,Atassi G

更新日期：1982-06-01 00:00:00

abstract：:Since 1975, 191 patients with Hodgkin's disease have been treated with a combination of chlorambucil, vinblastine, procarbazine and prednisolone (ChlVPP). Complete remission rates were 73% for previously untreated patients, 91% for patients previously treated with radiotherapy and 55% for patients previously treated w...

journal_title：British journal of cancer

authors： Dady PJ,McElwain TJ,Austin DE,Barrett A,Peckham MJ

更新日期：1982-06-01 00:00:00

abstract：:I.p. or i.v. administration of Corynebacterium parvum (CP) to MF1 mice induces a generalized inflammatory response, associated with marked hepatosplenomegaly and accompanied by a pronounced granulomatous response in the liver. Injection of the Landschütz ascites carcinoma (LAC) 24 h after CP substantially reduced the ...

journal_title：British journal of cancer

authors： McIntosh LC,Pugh-Humphreys RG,Fraser RA,Thomson AW

更新日期：1982-04-01 00:00:00

abstract：:In vivo growth characteristics of myeloid leukaemia induced by whole-body irradiation of CBA/H male mice were examined in the strain of origin by procedures expected to enhance or depress immunological responses. Syngeneic growth in vivo (survival time and frequency of takes) was not modified by attempted active immun...

journal_title：British journal of cancer

authors： Meldrum RA,Mole RH

更新日期：1982-03-01 00:00:00

abstract：:We have evaluated the relation between cancer of the lower urinary tract ("bladder cancer") and the use of artificial sweeteners, by means of case-control studies in Manchester, U.K., and Nagoya, Japan, areas where extensive use occurred 30-40 years ago. In each area, a broadly based series of cases (555 in Manchester...

journal_title：British journal of cancer

authors： Morrison AS,Verhoek WG,Leck I,Aoki K,Ohno Y,Obata K

更新日期：1982-03-01 00:00:00

abstract：:The effects of cis-dichlorodiammine platinum II (DDP) on the intestinal mucosa and the kidney were studied after single and multiple treatments with intervals of 7-45 days. After a single treatment, the jejunal epithelium underwent a transient interruption of cell proliferation followed by a hyperplastic recovery and ...

journal_title：British journal of cancer

authors： Kovacs CJ,Braunschweiger PG,Schenken LL,Burholt DR

更新日期：1982-02-01 00:00:00

abstract：:Fc-receptor-bearing cells forming EA rosettes with antibody-coated human erythrocytes (Ripley) were studied in cell suspensions and in purified preparations of mononuclear cells (MC) from 20 human malignant tumours. The EA rosettes were studied in preparations made by cytocentrifugation and the rosette-forming cells i...

journal_title：British journal of cancer

authors： Svennevig JL,Andersson TR

更新日期：1982-02-01 00:00:00

abstract：:The characteristics of 7 human melanoma cell lines were compared with those of the xenografts from which they were established. The ultrastructure, melanin content, isozyme pattern and chromosome numbers of the cell lines were closely similar to those of the corresponding xenografts. The different cell lines gave rise...

journal_title：British journal of cancer

authors： Tveit KM,Pihl A

更新日期：1981-12-01 00:00:00

abstract：:Oestrogen (RE) and progesterone (RP) cytosolic receptors have been studied in 59 clinically inflammatory tumours of the human breast. The results were compared to those obtained in a series of 496 operable tumours. A single saturating dose of oestradiol for RE and R 5020 for RP was used and the cut-off between negativ...

journal_title：British journal of cancer

authors： Delarue JC,May-Levin F,Mouriesse H,Contesso G,Sancho-Garnier H

更新日期：1981-12-01 00:00:00

abstract：:In a clinical investigation of observed postoperative survival, 563 patients have been registered for primary surgical treatment of colorectal cancer since 1974. The potential prognostic factors examined within the first days of hospitalization for primary resection included age of the patients, operability, location ...

journal_title：British journal of cancer

authors： Staab HJ,Anderer FA,Brümmendorf T,Stumpf E,Fischer R

更新日期：1981-11-01 00:00:00

abstract：:The hybrid cell line BH2 was derived by fusion between an AKR thymoma BW5147 (HGPRT-) and C57BL thymoma EL-4R (TK-). The hybrid cells showed a near-tetraploid modal number of chromosomes, in contrast to the near-diploid stem-lines of both parental cell populations; most of the BH2 hybrid cells acquired marker chromoso...

journal_title：British journal of cancer

authors： Bubeník J,Perlmann P,Jónsdóttir I,Kypĕnová H,Bubeníková D,Símová J

更新日期：1981-11-01 00:00:00

abstract：:Two soft-agar methods for assaying chemosensitivity of human cancers in vitro were compared with respect to colony morphology, plating efficiency (PE) and chemosensitivity of human melanomas. In 9 xenografts and 9 patients' biopsy specimens Method A (essentially that of Courtenay & Mills, 1978) gave considerably highe...

journal_title：British journal of cancer

authors： Tveit KM,Endresen L,Rugstad HE,Fodstad O,Pihl A

更新日期：1981-10-01 00:00:00

abstract：:Eleven groups of workers submitted a total of 21 bronchial tumour-associated antigen preparations and 19 antisera for comparative studies. Many of the antisera proved to be polyspecific despite absorption procedures. Most of the antigen preparations contained some material reactive towards a reference antiserum to nor...

journal_title：British journal of cancer

authors： Gennings JN,Bagshawe KD,Axelsen NH,Sizaret P

更新日期：1981-10-01 00:00:00